Join the PRINCIPLE Trial and Help the Fight Against COVID-19

PRINCIPLE is a nationwide clinical study from the University of Oxford to find COVID-19 treatments for recovery at home.

We are looking for medicines that can help people with COVID-19 symptoms get better quickly and stop them needing to go to hospital. PRINCIPLE is recruiting participants through this website and also through GP practices across the UK.
PRINCIPLE is still open to those who have received a COVID-19 vaccine.

If you have COVID-19 symptoms or a positive test, you may be eligible to join the PRINCIPLE trial and help the search for new treatments from the comfort of your own home.

Who is eligible to join PRINCIPLE:

  • You have been experiencing COVID-19 symptoms for less than 15 days
  • AND: You are aged 65 or over
  • OR: You are aged over 18 with an underlying health condition
  • OR: You are aged 18 or over with breathlessness associated with COVID-19

Please view the PRINCIPLE Trial COVID-19 poster or visit the PRINCIPLE Trial website for more information.